Fraunhofer Project Center for Stem Cell Process Engineering
In the age of automation and digitalization, the demands on cell cultures in terms of quality management and characterization have risen immensely. Reproducible and verifiable research in the field of pharmaceuticals development and testing as well as for medicinal products is essential in terms of cell tests, and has to be carried out on a cost-efficient basis.
For this purpose, the project center conceives algorithms especially or adapts commercial solutions to evaluate real-time-based optical cell measurements and supply reliable parameters with regard to proliferation, migration, morphology etc. for the categorization and characterization of cell systems. On the basis of these parameters, decisions can be made for the further procedure in cell culture or for the differentiation process of the induced pluripotent stem cells (iPSC).
Another focus point involves the analysis and simulation of fluid-kinetic, chemical and mechanical parameters of biological or chemical reactors and on-chip devices. These simulations are based on finite-element systems, and allow adaptive design as well as low-cost, materials-efficient development.